Publications

( Google Scholar page )

Journal Articles

Z Jiang, G Li, EF Lock. BAMITA: Bayesian Multiple Imputation for Tensor Arrays. Biostatistics, to appear, 2024
(arXiv pdf) (R code)

EF Lock. Empirical Bayes linked matrix decomposition. Machine Learning, 113: 7451-7477, 2024.

KE Johnson, N Hernandez-Alvarado, M Blackstad, T Heisel, M Allert, DA Fields, E Isganaitis, KM Jacobs, D Knights, EF Lock, MC Rudolph, CA Gale, MR Schleiss, FW Albert, EW Demerath, R Blekhman. Human Cytomegalovirus in breast milk is associated with milk composition and the infant gut microbiome and growth. Nature Communications , 15: 6216, 2024.
(link)

S Samorodnitsky, CH Wendt, EF Lock. Bayesian Simultaneous Factorization and Prediction Using Multi-Omic Data. Computational Statistics and Data Analysis , 197: 107974, 2024
(link) (arXiv pdf) (R package)

CT Rohloff, N Kohli, EF Lock. Identifiability and estimability of Bayesian linear and nonlinear crossed random effects models . British Journal of Mathematical and Statistical Psychology, doi: 10.1111/bmsp.12334, 2024.
(link)

BJ Sandri, J Kim, GR Lubach, EF Lock, E Ennis-Czerniak, PJ Kling, MK Georgieff, CL Coe, RB Rao. Prognostic Performance of Hematological and Serum Iron and Metabolite Indices for Detection of Early Iron Deficiency Induced Metabolic Brain Dysfunction in Infant Rhesus Monkey . The Journal of Nutrition, 10.1016/j.tjnut.2023.10.031, 2023.
(link)

J Wang, EF Lock. Multiple Augmented Reduced Rank Regression for Pan-Cancer Analysis. Biometrics, 80(1):ujad002, 2024.
(link) (arXiv pdf) (R package)

B Sandri, K Ennis-Czerniak, P Kanajam, W Frey, EF Lock, R Rao. Intranasal Insulin Treatment Partially Corrects the Altered Gene Expression Profile in the Hippocampus of Developing Rats with Perinatal Iron Deficiency . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, doi: 10.1152/ajpregu.00311.2022, 2023.
(link)

WJ Bosl, MB Enlow, EF Lock, CA Nelson. A biomarker discovery framework for childhood anxiety. Frontiers in Psychiatry, 14: 1158569, 2023.
(link) (news)

KA Peterson, CS Carlin, LI Solberg, §J Normington, EF Lock. Care Management Processes Important for High Quality Diabetes Care . Diabetes Care, dc222372, 2023.
(link)

J Kim, BJ Sandri, RB Rao, EF Lock. Bayesian predictive modeling of multi-source multi-way data, Computational Statistics and Data Analysis , 186: 107783, 2023, 2023.
(link) (arXiv pdf) (R code)

Y Peralta, N Kohli, P Kendeou, ML Davison, EF Lock. Modeling the Interrelation of Reading and Mathematics Achievement Trajectories: Is their Development Intertwined? {Reading and Writing, doi: 10.1007/s11145-023-10442-2, 2023.
(link)

DM MacDonald, S Samorodnitsky, CH Wendt, JV Baker, G Collins, M Kruk, EF Lock, R Paredes, S Poongulali, DO Weise, A Winston, R Wood, KM Kunisaki. Pneumoproteins and biomarkers of inflammation and coagulation do not predict rapid lung function decline in people living with HIV. Scientific Reports, 13: 4749, 2023.
(link)

S Samorodnitsky, EF Lock, M Kruk, A Morris, JM Leung, KM Kunisaki, TJ Griffin, CH Wendt. Lung proteome and metabolome endotype in HIV-associated obstructive lung disease. ERJ Open Research, 9 (2), 2023.
(link)

RB Rao, G Lubach, K Ennis-Czerniak, EF Lock, P Kling, MK Georgieff, C Coe. Reticulocyte Hemoglobin Equivalent has Comparable Predictive Accuracy as Conventional Serum Iron Indices for Predicting Iron Deficiency and Anemia in a Nonhuman Primate Model of Infantile Iron Deficiency. Journal of Nutrition, 153(1):148- 157, 2023. (link)

B Sandri, J Kim, G Lunach, EF Lock, C Guerrero, L Higgings, T Markowski, P Kling, M Georgieff, C Coe, R Rao. Tandem mass tag proteomic and untargeted metabolomic profiling reveals altered serum and CSF biochemical datasets in iron deficient monkeys. Data in Brief, 45: 108591, 2022. PMID: 36164307
(link)

B Guo, LE Eberly, PG Henry, C Lenglet, EF Lock. Multiway sparse distance weighted discrimination. Journal of Computational and Graphical Statistics, in press, 2022.
(link) (arXiv pdf) (R code)

CH Wendt, S Samorodnitsky, EF Lock, M Kruk, A Morris, JM Leung, KM Kunisaki, TJ Griffin. The lung and plasma metabolome in HIV-associated obstructive lung disease. Journal of Acquired Immune Deficiency Syndrome, 10.1097/QAI.0000000000003061, 2022. PMID: 35849661
(link)

S Samorodnitsky, KA Hoadley, EF Lock. A Hierarchical Spike-and-Slab Model for Pan-Cancer Survival Using Pan-Omic Data. BMC Bioinformatics, 23: 235, 2022. PMID: 35710340
(link) (arXiv pdf) (R code)

EF Palzer, C Wendt, R Bowler, CP Hersh, SE Safo, EF Lock. sJIVE: Supervised Joint and Individual Variation Explained. Computational Statistics and Data Analysis, 175: 107547, 2022. (PMID: 36119152)
(link) (arXiv pdf) (R code)

S Priya, MB Burns, T Ward, RAT Mars, B Adamowicz, EF Lock, PC Kashyap, D Knights, R Blekhman. Shared and disease-specific host gene-microbiome associations across human diseases. Nature Microbiology, 7: 780-795, 2022. PMID: 35577971
(link)

B Sandri, §J Kim, G Lunach, EF Lock, C Guerrero, L Higgings, T Markowski, P Kling, M Georgieff, C Coe, R Rao. Multiomic Profiling of Iron Deficient Infant Monkeys Reveals Alterations in Neurologically Important Biochemicals in Serum and CSF Prior to the Onset of Anemia. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 322 (6): R486-500, 2022. PMID: 35271351
(link)

EF Lock. Bayesian Distance Weighted Discrimination. Journal of Computational and Graphical Statistics, 31 (4): 1177-1188, 2022. PMID: 36465095
(link) (arXiv pdf) (R code)

J Normington, EF Lock, TA Murray, CS Carlin. Bayesian variable selection in hierarchical difference-in-differences models. Statistical Methods in Medical Research, 31 (1): 169-183, 2022. PMID: 34841979
(link) (arXiv pdf) (R code)

EF Lock, J Park, KA Hoadley. Bidimensional linked matrix factorization for pan-omics pan-cancer analysis. Annals of Applied Statistics, 16 (1): 193-215, 2022. PMID: 35505906
(link) (arXiv pdf) (R code)

BJ Sandri, GR Lubach, EF Lock, MK Georgieff, PJ King, CL Coe and RB Rao. Correcting Iron Deficiency Anemia with Iron Dextran Alters the Serum Metabolomic Profile of the Infant Rhesus Monkey. American Journal of Clinical Nutrition 113 (4): 915-923, 2021. PMID: 33740040
(link) (R code)

EF Lock and D Bandyopadhyay. Bayesian nonparametric multiway regression for clustered binomial data. Stat, 10 (1):e378, 2021. PMID: 35419192
(link) (arXiv pdf) (R code) (Results)

Y Peralta, N Kohli, EF Lock, ML Davison. Bayesian modeling of associations in bivariate piecewise linear mixed-effects models. Psychological Methods, 2020. PMID: 33030911
(link) (R code)

DJ Beisang, K Smith, A Gilbertson, A Bunyemov, J Herrera, EF Lock, E Racila, C Forster, CA Henke, and PB Bitterman. Single-cell RNA sequencing reveals that lung mesenchymal progenitor cells in IPF exhibit pathological features early in their differentiation trajectory. Scientific Reports, 10: 11162, 2020. PMID: 32636398
(link)

S Samorodnitsky, KA Hoadley, and EF Lock. A Pan-Cancer and Polygenic Bayesian Hierarchical Model for the Effect of Somatic Mutations on Survival. Cancer Informatics, 19: 1176935120907399, 2020. PMID:32116467
(link) (arXiv pdf) (R code) (Results)

BJ Sandri, GR Lubach, EF Lock, MK Georgieff, PJ King, CL Coe and RB Rao. Early-Life Iron Deficiency and Its Natural Resolution Are Associated with Altered Serum Metabolomic Profiles in Infant Rhesus Monkeys. The Journal of Nutrition, 150 (4): 685-693, 2020. PMID: 31722400
(link)

J Park and EF Lock. Integrative Factorization of Bidimensionally Linked Matrices. Biometrics, 76 (1): 61-74, 2020. PMID:31444786
(link) (arXiv pdf) (R code)

A Kaplan, EF Lock, M Fiecas. Bayesian GWAS with Structured and Non-Local Priors. Bioinformatics, 36 (1): 17–25, 2020. PMID:31651034
( link ) ( R package)

J Normington, EF Lock, C Carlin, K Peterson, BP Carlin. A Bayesian difference-in-difference framework for the impact of primary care redesign on diabetes outcomes. Statistics in Public Policy, 6 (1): 55-66, 2019. PMID:31435498
(link)

AM Siddappa, GM Quiggle, EF Lock, RB Rao. Predictors of severe intraventricular hemorrhage in preterm infants under 29-weeks gestation. Journal of Maternal and Fetal Neonatal Medicine, doi: 10.1080/14767058.2019.1601698, 2019. PMID:30995877

MJ O'Connell and EF Lock. Linked Matrix Factorization. Biometrics, 75 (2): 582-592, 2019.
PMID:30516272
(link) ( arXiv pdf) (R code)

H Zhu, G Li, and EF Lock. Generalized Integrative Principal Component Analysis for Multi-Type Data with Block-Wise Missing Structure. Biostatistics, 21 (2): 302–318, 2020.
(link) ( arXiv pdf) (R code)

BJ Sandri, A Kaplan, SW Hodgson, M Peterson, S Avdulov, LA Higgins, T Markowski, P Yang, AH Limper, TJ Griffin, P Bitterman, EF Lock and CH Wendt. Multi-Omic Molecular Profiling of Lung Cancer Risk in Chronic Obstructive Pulmonary Disease. European Respiratory Journal, 52(1): 1702665, 2018. PMID:29794131

EF Lock and G Li. Supervised multiway factorization. Electronic Journal of Statistics, 12 (1): 1150-1180, 2018. PMID:29675120
( pdf ) (Matlab code)

EF Lock, N Kohli and M Bose. Detecting Multiple Random Changepoints in Bayesian Piecewise Growth Mixture Models. Psychometrika, 83 (3): 733-750, 2018. PMID:29150814
( arXiv preprint) (R package)

EF Lock. Tensor-on-tensor regression. Journal of Computational and Graphical Statistics, 27 (3): 638-647, 2018.
( arXiv preprint) (R package)

R Rao, K Ennis, G Lubach, EF Lock, M Georgieff, and C Coe. Metabolomic Analysis of CSF Indicates Brain Metabolic Impairment Precedes Hematological Indices of Anemia in the Iron-Deficient Infant Monkey. Nutritional Neuroscience, 21 (1):40-48, 2018.
( PubMed link)

A Kaplan and EF Lock. Prediction with Dimension Reduction of Multiple Molecular Data Sources for Patient Survival. Cancer Informatics, 16: 1-11, 2017. PMID:28747816
(link) (pdf) (video abstract)

T Lyu, EF Lock and LE Eberly. Discriminating sample groups with multi-way data. Biostatistics, 18 (3): 434-450, 2017. PMID: 28115314
( pdf) ( R package)

EF Lock and DB Dunson. Bayesian Genome- and Epigenome-wide Association Studies with Gene Level Dependence. Biometrics, 73 (3): 1018-1028, 2017. PMID:28083869
( arXiv pdf) ( R package)

MJ O'Connell and EF Lock. R.JIVE for exploration of multi-source molecular data. Bioinformatics, 32(18):2877-2879, 2016.
(PubMed link) (pdf) (R package)

EF Lock and DB Dunson. Shared kernel Bayesian screening. Biometrika, 102 (4):829-842, 2015. PMID: 27046939
( link) ( R code) ( arXiv pdf)

J Kuligowski, D Perez-Guaita, A Sanchez-Illana, Z Leon-Gonzalez, M de la Auardia, M Vento, EF Lock, G Quintas. Analysis of multi-source metabolomic data using joint and individual variation explained (JIVE). Analyst, 2015, 140, 4521-4529.
( link)

EF Lock, K Soldano, ME Garrett, H Cope, CA Markunas, H Fuchs, G Grant, DB Dunson, SG Gregory, AE Ashley-Koch. Joint eQTL Assessment of Whole Blood and Dura Mater Tissue from Individuals with Chiari Type I Malformation. BMC Genomics, 16:11, 2015.
(link)

CA Markunas, EF Lock, K Soldano, H Cope, CC Ding, DS Enterline, G Grant, H Fuchs, AE Ashley-Koch, SG Gregory. Identification of Chiari Type I Malformation subtypes using whole genome expression profiles and cranial base morphometrics. BMC Medical Genomics, 7:39, 2014.
(link)

J Zhang, D Jima, Q Liu, A Moffitt, M Czader, Y Fedoriw, K Richards, Z Sun, C Love, P Scotland, EF Lock, S Levy, DB Dunson, and S Dave. The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. Blood, 123 (19):2988-2996, 2014.
(link)

EF Lock and DB Dunson. Bayesian consensus clustering. Bioinformatics, 29 (20): 2610-2616, 2013.
(link) (arXiv) (software) (Bioinformatics pdf) (Bioinformatics supplement)

EF Lock, KA Hoadley, JS Marron, and AB Nobel. Joint and Individual Variation Explained (JIVE) for Integrated Analysis of Multiple Data Types. Annals of Applied Statistics, 7(1):523-542, 2013.
(link) (software) (arXiv)

DM Reif, M Sypa, EF Lock, FA Wright, A Wilson, T Cathey, RR Judson, and I Rusyn. ToxPi GUI: An interactive visualization tool for transparent integration of data from diverse sources of evidence. Bioinformatics, 29(3):402-403, 2013.
(link) (software)

EF Lock, N Abdo, O Kosyk, SH O'shae, R Huang, M Xia, YH Zhou, A Sedykh, A Tropsha, CP Austin, RR Tice, FA Wright and I Rusyn. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model.. Toxicological Sciences, 126(2): 578-588, 2012.
(link) (related blog post)

EF Lock, AB Nobel, and JS Marron. Comment: Population Value Decomposition, a Framework for the Analysis of Image Populations. Journal of the American Statistical Association, 106(495):798-802, 2011.
(link) (pdf)

BU Bradford, EF Lock, O Kosyk, S Kim, T Uehara, D Harbourt, M DeSimone, DW Threadgill, V Tryndyak, IP Pogribny, L Bleyle, DR Koop, and I Rusyn. Inter-strain differences in the liver effects of trichloroethylene in a multi-strain panel of inbred mice. Toxicological Sciences , 120(1):206-217, 2011.
(link) (data)

EF Lock, R Ziemiecki, D Dittmer, and JS Marron. Efficiency clustering for low-density microarrays and its application to QPCR. BMC Bioinformatics, 11:386, 2010.
(link) (software)

S Yeo, J Cisewski, EF Lock, JS Marron. Exploratory Analysis of Exercise Adherence Patterns With Sedentary Pregnant Women. Nursing Research, 59(4):280-287, 2010.
(link)

RM Frongillo, EF Lock, DM Brown. Symmetric fractal trees in three dimensions. Chaos, Solitons & Fractals, 32(2):284-295, 2007.
(link)

Books & Book Chapters

EF Lock and AB Nobel Exploratory methods to integrate multisource data. In GC Tseng, D Ghosh & XJ Zhou (Eds), Integrating Omics Data, pp. 242-268. Cambridge University Press, Cambridge, UK. 2015.
(Chapter preprint) (Book link)

RH Lock, PF Lock, KL Morgan, EF Lock, and DF Lock. Statistics: Unlocking the Power of Data. John Wiley & Sons, Hoboken, NJ, 2012.
2nd Edition: 2017
(Website)